| Autor: |
P O, Katz, G G, Ginsberg, P E, Hoyle, M B, Sostek, J T, Monyak, D G, Silberg |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Alimentary pharmacologytherapeutics. 25(5) |
| ISSN: |
0269-2813 |
| Popis: |
To assess the relationship between the percentage of time intragastric pH4.0 and healing of erosive oesophagitis.In this proof-of-concept study, adults with endoscopically verified Los Angeles grade C or grade D erosive oesophagitis were randomly assigned to oral esomeprazole 10 or 40 mg once daily for 4 weeks. On day 5, patients underwent 24-h pH monitoring. At 4 weeks, erosive oesophagitis healing status was endoscopically assessed. Investigators scored gastro-oesophageal reflux disease symptoms on a 4-point scale [none to severe (0-3)] before and 4 weeks after treatment. The percentage of time intragastric pH was4.0 and healing status were correlated and tested for significance using a Spearman rank correlation (r).103 patients had evaluable data (mean age, 48.7 years; 65% men). Mean percentages of time with intragastric pH4.0 on day 5 in patients with healed and unhealed erosive oesophagitis were 61% and 42%, respectively (P = 0.0002), indicating that erosive oesophagitis healing rates were positively related to the percentage of time intragastric pH was4.0. Greater intragastric acid control correlated with lower final daytime and night-time heartburn and acid regurgitation symptom scores (r = -0.029, -0.029 and -0.021; P = 0.003, 0.003 and 0.032, respectively).A positive relationship between intragastric acid control and erosive oesophagitis healing was demonstrated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
