| Autor: |
Sawh, Mary Catherine, Newton, Kimberly P., Goyal, Nidhi P., Angeles, Jorge Eduardo, Harlow, Kathryn, Bross, Craig, Schlein, Alexandra N., Hooker, Jonathan C., Sy, Ethan Z., Glaser, Kevin J., Yin, Meng, Ehman, Richard L., Sirlin, Claude B., Schwimmer, Jeffrey B. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
J Magn Reson Imaging |
| Popis: |
BACKGROUND: Magnetic resonance elastography (MRE) can determine presence and stage of liver fibrosis. Data on normative MRE values, while reported in adults, are limited in children. PURPOSE: To determine distribution of MRE-measured liver stiffness in children without liver disease. STUDY TYPE: Prospective, observational POPULATION: 81 healthy children, (mean 12.6 ± 2.6 years, range 8–17 years) FIELD STRENGTH/SEQUENCE: 3.0 Tesla Signa HDxt, General Electric MR Scanner; 2D GRE MRE sequence ASSESSMENT: History, examination, laboratory evaluation, and (MR) exams (PDFF and MRE) were performed. MR elastograms were analyzed manually at two reading centers and compared with each other for agreement and with published values in healthy adults and thresholds for fibrosis in adult and pediatric patients. STATISTICAL TESTS: Descriptive statistics, Bland Altman analysis, t-test to compare hepatic stiffness values with reference standards. RESULTS: Stiffness values obtained at both reading centers were similar without significant bias (p=0.362) and with excellent correlation (ICC =0.782). Mean hepatic stiffness value for the study population was 2.45 ± 0.35 kPa (95(th) percentile 3.19 kPa) which was significantly higher than reported values for healthy adult subjects (2.10 kPa ± 0.23 kPa, p < 0.001). 74–85% of subjects had stiffness measurements suggestive of no fibrosis. CONCLUSION: Mean liver stiffness measured with MRE in this cohort were significantly higher than reported in healthy adults. Despite rigorous screening, some healthy children had stiffness measurements suggestive of liver fibrosis using current published thresholds. Although MRE has the potential to provide noninvasive assessment in patients with suspected hepatic disease, further refinement of this technology will help advance its use as a diagnostic tool for evidence of fibrosis in pediatric populations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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