| Autor: |
Kanai Lal, Barik, Uttam Kumar, Paul, Anup Kumar, Bhattacharyya, Amit, Adhikary, Gajanand, Agarwal, Kriti Sundar, Rana |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Journal of the Indian Medical Association. 112(2) |
| ISSN: |
0019-5847 |
| Popis: |
Epilepsy is a common paediatric neurologic disorder that is difficult to manage in a substantial portion of children, highlighting the continued need for more effective and better tolerated drugs. A multicentric study was conducted from August, 2011 to July, 2013 using levetiracetam (LEV) in newely diagnosed epilepsy in 122 young children of 1-5 years age group to find its role in practical scenario depending upon the knowledge from prior literature available. It has been demonstrated effective as adjunctive therapy as well as monotherapy for new-onset partial seizures and generalised tonic-clonic seizures (GTCS) but it acts better as adjunctive therapy than the monotherapy. When LEV was used as adjunctive therapy 15.4% children with partial seizure were seizure-free as compared to 11.12% in GTCS and when LEV was used as monotherapy 16.17% children with partial seizure were seizure-free as compared to 15.38% in GTCS. When LEV was used as add on therapy 16.67% children2 years were seizure-free as compared to 17.85% in2 years. When LEV was used as monotherapy 25.00% children2 years were seizure-free as compared to 18.18%2 years. So, it was found more efficacious in partial group of seizures than the GTCS variety. It also shows more efficacy in older age group (2 years) than the younger ones (2 years). Somnolence and behavioural changes were noted as ad- verse effects in a few cases. So, LEV is an important addition to the treatment of paediatric epilepsy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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