Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide

Autor:	C, Dwivedi, S, Rohlfs, D, Jarvis, F N, Engineer
Rok vydání:	1992
Předmět:	Allyl Compounds Mice Plants Medicinal Skin Neoplasms Papilloma 9 10-Dimethyl-1 2-benzanthracene Body Weight Animals Tetradecanoylphorbol Acetate Antineoplastic Agents Disulfides Sulfides Garlic
Zdroj:	Pharmaceutical research. 9(12)
ISSN:	0724-8741
Popis:	Garlic and onion oil have been shown to inhibit chemically induced skin tumor development in mice. In the present study, the effects of diallyl sulfide and diallyl disulfide, oil-soluble constituents of garlic and onion, on 7,12-dimethylbenz(a)anthracene-induced and 12,O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation were examined in SENCAR mice. Topical application of diallyl sulfide or diallyl disulfide significantly inhibited skin papilloma formation from the ninth week of promotion and significantly increased the rate of survival in the murine model. Our findings support earlier evidence that these naturally occurring compounds may be useful for the chemoprevention of certain types of tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d7dec96d2ce7a2b65f2b46b610455c2d https://pubmed.ncbi.nlm.nih.gov/1488416 Zobrazit plný text záznamu Full text from SpringerLink