[Funtional study of gene relA in the expression of amino acid operons. III. The effect of the allelic state of gene relA on the derepression of the threonine and isoleucine-valine operons of Escherichia coli K-12]

Autor:	G G, Zaigraeva, R S, Shakulov, M M, Gusiatiner, V A, Livshits, N I, Zhdanova
Rok vydání:	1980
Předmět:	Threonine Genes Threonine Dehydratase Transcription Genetic Protein Biosynthesis Operon Escherichia coli Homoserine Dehydrogenase Valine Amino Acids Isoleucine Alleles
Zdroj:	Genetika. 16(2)
ISSN:	0016-6758
Popis:	During the derepression of threonine and isoleucine-valine operons the increase of activity of homoserine dehydrogenase and threonine deaminase respectively occurs only in relA+ strains of Escherichia coli K-12, while the activity of these enzymes in relA mutants does not change. The increase of the activity of homoserine dehydrogenase in relA+ strains corresponds to the increase of the fraction of the thr-mRNA, i.e. the expression of threonine operon is regulated at the level of transcription. After isoleucine is exhausted, only relA+ cells of threonine producer MG442 increase homoserine dehydrogenase activity and production of threonine. Thus, the regulation of transcription and translation of threonine and isoleucine-valine operons depends upon the allelic state of the relA gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d7d7dee9222c67242c044b98d2597c11 https://pubmed.ncbi.nlm.nih.gov/6986324 Zobrazit plný text záznamu