| Autor: |
J E, Byfield, W, Stanton, T R, Sharp, S S, Frankel, J, Koziol |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Cancer treatment reports. 67(10) |
| ISSN: |
0361-5960 |
| Popis: |
Thirty patients with locally advanced nonresectable non-small cell bronchogenic carcinoma were studied for tolerance and response to 120-hour continuously infused 5-FU (IFU) combined with chest x-ray therapy. The IFU was escalated in patient groups from 20 to 35 mg/kg/24 hours. Radiation was also escalated in patient subsets from 200 to 400 rads/fraction using a split-course technique to a total dose of 5000 rads. Tolerance was exceeded by IFU doses of 35 mg/kg/day. The complete response rate was ten of 28 patients (36%); a complete response was associated with a significantly prolonged survival. Radiosensitization of lung cancer by IFU appears clinically feasible in man. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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