[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
| Autor: | C, Matthias, V, Jahnke, A A, Fryer, R C, Strange |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Polymorphism Genetic Genotype Tumor Necrosis Factor-alpha Genetic Variation Neoplasms Second Primary Middle Aged Isoenzymes Neoplasms Multiple Primary Otorhinolaryngologic Neoplasms Cytochrome P-450 Enzyme System Gene Frequency Reference Values Risk Factors Carcinoma Squamous Cell Humans Female Genetic Predisposition to Disease Alleles Aged Follow-Up Studies Glutathione Transferase Microsatellite Repeats |
| Zdroj: | Laryngo- rhino- otologie. 82(1) |
| ISSN: | 0935-8943 |
| Popis: | The polymorphic gene loci of the detoxifying enzymes GST and CYP are susceptibility factors for single head and neck cancer. In patients with multiple cancer development a cumulation of genetic risk factors can be assumed.Accordingly, we have examined genotype frequencies at GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A1, CYP2E1, and TNF loci, in patients with single and multiple squamous cell carcinoma (SCC) of the head and neck, and controls.GSTT1 0 was increased in multiple SCC patients (36.8 %) compared with single SCC patients (21.2 %) and controls (22.2 %). GSTM3 AA was more frequent in the single SCC patients (76.6 %) and multiple SCC patients (82.1 %) compared with controls (66.5 %) but lacked significance. The TNF allele B3 was significantly increased in the single SCC group (B3-allele: 22.5 %, B3/B3 : 10.8 %) and showed a further cumulation in the multiple SCC group (B3 : 30.3 %, B3/B3 : 15.8 %).Patients suffering from multiple SCC development showed a cumulation of high risk genotypes at GST and TNF gene loci. Specific genetic variations could not be determined. |
| Databáze: | OpenAIRE |
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