The fat/fiber antagonism in experimental colon carcinogenesis

Autor:	J L, Trudel, M K, Senterman, R A, Brown
Rok vydání:	1983
Předmět:	Dietary Fiber Male Body Weight Colonic Neoplasms Animals Rats Inbred Strains Adenocarcinoma Dietary Fats Rats
Zdroj:	Surgery. 94(4)
ISSN:	0039-6060
Popis:	Current epidemiologic and experimental data emphasize the importance of nutrition in colon carcinogenesis. The interactions between dietary fat and dietary fiber were studied in the dimethylhydrazine model for colon cancer. A strict pair-feeding system was developed, and rats were fed one of five semisynthetic diets containing various amounts and types of fat and fiber. The incidence and number of tumors per animal were increased in all fat-fed groups. Adding fiber to the diets provided either partial (polyunsaturated fat) or complete (saturated fat) protection against the deleterious effect of fat. The antagonism between fat and fiber and the clinical relevance of these data are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d78b62a0d4140b676ffc816a9f3db903 https://pubmed.ncbi.nlm.nih.gov/6312623 Zobrazit plný text záznamu