| Autor: |
M, Kose, N, Senkal, T, Tukek, T, Cebeci, S C, Atalar, M, Altinkaynak, H, Arici, S, Genc, Y, Catma, M, Kocaaga, A, Medetalibeyoglu, S, Emet |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
European review for medical and pharmacological sciences. 26(19) |
| ISSN: |
2284-0729 |
| Popis: |
Vitamin D has beneficial effects, some of which involve the cardiovascular system. No study to date has investigated the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels in the absence of subclinical atherosclerosis detected by carotid intima-media thickness (CIMT) in healthy individuals.Subjects were categorized into three groups based on vitamin D levels according to Endocrine Society guidelines. Mean CIMT was calculated from six measurements on two scans. Statistical significance was set at p0.05, and all testing was two-sided.The concentration of serum endocan was 802.8 ± 411.4 ng/L in the group with the lowest serum vitamin D level, 454.8 ± 334.3 ng/L in the mild/moderately low serum vitamin D level group, and 269.4 ± 180.2 ng/L in the group with normal serum vitamin D levels (p0.01). Receiver operating characteristics curve analysis revealed that a serum vitamin D concentration of 7.5 ng/mL had a 97% sensitivity and 81% specificity for the prediction of serum endocan level greater than 270 ng/L, which could be an indicator for endothelial inflammation.Demonstrating that vitamin D deficiency can cause endothelial damage in the early period of atherosclerosis without the development of clinical cardiovascular disease will have a pivotal role in the prevention of cardiovascular mortality and morbidity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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