Synthesis and antimicrobial activity of some tetramethylenethieno[2,3-d]pyrimidine derivatives

Autor:	K A, Ismail, O M, Aboulwafa, E A, Koreish
Rok vydání:	1995
Předmět:	Staphylococcus aureus Antifungal Agents Magnetic Resonance Spectroscopy Pyrimidines Anti-Infective Agents Spectrophotometry Infrared Candida albicans Escherichia coli Microbial Sensitivity Tests Thiophenes Anti-Bacterial Agents
Zdroj:	Farmaco (Societa chimica italiana : 1989). 50(9)
ISSN:	0014-827X
Popis:	A series of tetramethylenethieno[2,3-d]pyrimidine derivatives has been synthesized and tested for its antimicrobial properties. All the synthesized compounds were found to exhibit in vitro antibacterial and/or antifungal activity. The highest activity was elicited by 4-benzolhydrazino-5,6-tetramethylenethieno[2,3-d]pyrimidine (9) showing MIC value of 7.81 micrograms/ml against E. Coli and C. albicans, while its MBC value was half that of nystatin. Compound 16 was almost as potent as nystatin exhibiting a minimum bactericidal concentration (MBC) value of 15.62 micrograms/ml.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d713f41eb3d30cae353cbfa29be71142 https://pubmed.ncbi.nlm.nih.gov/7495472 Zobrazit plný text záznamu