Effects of L-Serine Against Cisplatin-Mediated Reactive Oxygen Species Generation in Zebrafish Vestibular Tissue Culture and HEI-OC1 Auditory Hybridoma Cells

Autor:	Jerry D, Monroe, Satya A, Moolani, Elvin N, Irihamye, Alexandra M, Johnston, Michael E, Smith
Rok vydání:	2019
Předmět:	Male Tissue Culture Techniques Hybridomas Cell Line Tumor Serine Animals Female Cisplatin Saccule and Utricle Reactive Oxygen Species Zebrafish
Zdroj:	Neurotoxicity research. 39(1)
ISSN:	1476-3524
Popis:	Cisplatin is a platinum-based chemotherapy compound effective against a variety of cancers. However, it can cause increased reactive oxygen species (ROS) production in auditory and vestibular tissue leading to permanent hearing and balance loss. The amino acid, L-serine, has been shown to reduce ROS in some tissue types. In this project, we first investigated whether L-serine could reduce cisplatin-mediated ROS generation in zebrafish utricular tissue culture using spectrophotometry and the fluorescent ROS detector dye, H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d6f5abbf17b28c2c578aa698fff4845a https://pubmed.ncbi.nlm.nih.gov/32221851 Zobrazit plný text záznamu Full text from SpringerLink