| Autor: |
H, Abou-Issa, R W, Curley, M J, Panigot, S N, Tanagho, B S, Sidhu, G A, Alshafie |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 17(5A) |
| ISSN: |
0250-7005 |
| Popis: |
The growth inhibitory effects of N-(4- Hydroxyphenyl) retinamide (4-HPR) and its glucuronide derivative, N-(4-Hydroxyphenyl) retinamide-O-glucuronide (4-HPROG) on established DMBA induced rat mammary tumors were compared. The results indicate that the glucuronide analog had a greater antitumor potency than equimolar concentration of the free retinoid. Tumor regression occurred in 75% of the rats fed 2 mmol/Kg diet of 4-HPROG. In a 6-week study, the maximum tolerated dietary dose (MTD) was found to be 3.5 mmol/Kg diet for 4-HPR and 5 mmol/Kg diet in the case of 4-HPROG. The higher potency and lower toxicity of the glucuronide suggests that this conjugate may have an in vivo chemotherapeutic advantage over the parent free retinoid. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
