| Autor: |
Efstathios, Vassiliadis, Claudia P, Oliveira, Mario R, Alvares-da-Silva, Chen, Zhang, Flair J, Carrilho, Jose T, Stefano, Fabiola, Rabelo, Leila, Pereira, Camila R, Kappel, Kim, Henriksen, Sanne Skovgård, Veidal, Ben, Vainer, Kevin L, Duffin, Claus, Christiansen, Diana J, Leeming, Morten, Karsdal |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
American journal of translational research. 4(4) |
| ISSN: |
1943-8141 |
| Popis: |
Aim: To investigate whether increased levels of vimentin citrullinated peptides identified by MS in articular cartilage can be measured in pathologies other than rheumatoid arthritis and be utilised for diagnostic purposes. Methods: A monoclonal antibody against the sequence RLRSSVPGV-citrulline (VICM) was developed and evaluated in a carbon tetrachloride (CCl4) (n=52 + 28 controls) rat model of liver fibrosis and two clinical cohorts of adult patients with hepatitis C (HCV) (n=92) and non-alcoholic fatty liver disease (NAFLD) (n=62), and compared to healthy controls. Results: In CCl4-treated rats, mean systemic VICM levels increased 31% at week 12 (176 ng/mL, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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