[Effect of plant melanin pigment on the clastogenic effects of chemical mutagens in mice]

Autor: T N, Alekseeva, A D, Durnev, A V, Kulakova, A V, Oreshchenko, L V, Samusenok, B N, Ogarkov, S B, Seredenin
Rok vydání: 2002
Předmět:
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia. 64(6)
ISSN: 0869-2092
Popis: The chromosome aberration assay in the bone marrow cells of C57BL/6 mice showed that melanin pigment (MP) in a dose range from 0.01 to 10 mg/kg does not influence the clastogenic effect of dioxidine (200 mg/kg, i.p.), while reducing the clastogenic effect of cyclophosphamide (20 mg/kg, i.p.) by a factor of 1.5-4 in various treatment regimes depending on the mutagen injection time.
Databáze: OpenAIRE