| Autor: |
S Y, Kim, M S, Nayak, M, Kita, M F, Marmor |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Investigative ophthalmologyvisual science. 35(2) |
| ISSN: |
0146-0404 |
| Popis: |
To determine the time course and reproducibility of electroretinogram recovery after short-term (5- to 20-minute) retinal ischemia in the light and in the dark.Electroretinogram recovery was measured in Dutch rabbits after 5-, 10-, or 20-minute episodes of ocular ischemia, repeated three times at 1-hour intervals. Results were compared under light- and dark-adapted conditions.The rate of b-wave recovery was highly reproducible after repetitive ischemic insults in the same eye. The rate of b-wave recovery varied in proportion to the duration of ischemia but generally reached 100% of preischemic levels within 45 to 60 minutes. Recovery was slower under dark-adapted conditions than under light-adapted conditions, and 10 minutes of ischemia appeared to be a critical duration to maximize light- and dark-adapted metabolic differences.Because of the speed and reproducibility of electroretinogram recovery, the use of short-term ischemic episodes may facilitate studies on the pharmacologic therapy of retinal ischemia. It remains to be determined, however, whether the retinal effects of short-term ischemia are mediated by the same mechanisms as the effects of longer-term ischemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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