| Autor: |
J, Rubio Briones, L, Morell Quadreny, J A, López Guerrero, J, Casanova Ramón-Borja, C, Mejía Vázquez, I, Iborra Juan, A, Pellín Pérez, E, Solsona Narbón, A, Llombart Bosch |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Actas urologicas espanolas. 26(3) |
| ISSN: |
0210-4806 |
| Popis: |
To know the basal membrane (BM) integrity in renal cell carcinoma (RC) and its importance as prognostic factor.73 patients with RC were selected. Immunohistochemistry with monoclonal antibodies against basal proteins laminin and collagen IV was performed. Percentage for BM fragmentation in the whole tumour was considered taking 75% as cut off.Follow-up was 6.3 +/- 4.3 years and 27 patients progressed. Correlation between laminin and collagen IV was significative (p = 0.000). A BM fragmentation expressed with laminin bigger than 75% was related to tumoural symptoms (p = 0.019), worse grade (p = 0.004) and necrosis in more than 10% of the tumour (p = 0.000). Fragmentation observed with collagen IV was associated to tumours greater than 7 cm (p = 0.014). Those patients whose tumours displayed more than 75% of BM fragmentation, measured with collagen IV, presented worse survival (p = 0.042). A similar trend was observed in the case of laminin, but it did not reach statistic significance (p = 0.119). In the unvariated analysis grade III-IV, more than 10% of necrosis within the tumour, tumoural symptoms and BM fragmentation bigger than 75% measured with collagen IV were prognostic, while only grade and necrosis did so in the multivariate analysis.Collagen IV and laminin represent nicely, with a similar expression pattern, the BM fragmentation in RC. Within a battery of immunohistochemical markers to study RC at least one of them should be included because their prognostic implication. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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