Polymerase chain reaction polymorphisms in HLA-DQ alpha and IL6 from Mongoloid and Caucasoid populations
| Autor: | N V, Titenko, J H, Kurth, A M, Bowcock, L L, Cavalli-Sforza |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
China
Polymorphism Genetic Base Sequence Interleukin-6 Molecular Sequence Data DNA Neoplasm Precursor Cell Lymphoblastic Leukemia-Lymphoma Polymerase Chain Reaction HLA-DQ alpha-Chains White People Europe Asian People HLA-DQ Antigens Humans Lymphocytes Oligonucleotide Probes Alleles Chromosomes Human Pair 7 USSR |
| Zdroj: | Biomedical science. 2(2) |
| ISSN: | 0955-9701 |
| Popis: | Polymerase chain reaction polymorphisms have been used to study European, Chinese, Russian and Buryat populations at the HLA-DQ alpha and IL6 loci. DNA from individuals in these populations was specifically amplified at these loci, and analyzed either with allele-specific oligonucleotides for HLA-DQ alpha or directly on agarose gels for IL6. Allelic frequencies were calculated for each of the loci in each population. Comparisons between the population frequencies show that the Russian population is more closely related to Europeans, and that the Buryat population is more closely related to Chinese. This finding is in agreement with conclusions based on the phenotypic frequencies of classical blood-group and other protein markers in these populations. |
| Databáze: | OpenAIRE |
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