Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect

Autor:	S-C, Yap, W, Drenthen, P G, Pieper, P, Moons, B J M, Mulder, H W, Vliegen, A P J, van Dijk, F J, Meijboom, V W V, Jaddoe, E A P, Steegers, E, Boersma, J W, Roos-Hesselink
Rok vydání:	2010
Předmět:	Adult Heart Septal Defects Ventricular Pregnancy Complications Cardiovascular Infant Newborn Pregnancy Outcome Pre-Eclampsia Pregnancy Recurrence Risk Factors Infant Small for Gestational Age Humans Premature Birth Female Retrospective Studies
Zdroj:	BJOG : an international journal of obstetrics and gynaecology. 117(6)
ISSN:	1471-0528
Popis:	To compare the risks of pregnancy complications in women with repaired and unrepaired isolated ventricular septal defect (VSD).A retrospective multicentre study.Tertiary centres in the Netherlands and Belgium.Women were identified using two congenital heart disease registries. Eighty-eight women were identified who had experienced 202 pregnancies, including 46 miscarriages and nine terminations of pregnancy. Information on each completed pregnancy (n = 147; unrepaired VSD, n = 104; repaired VSD, n = 43) was obtained using medical records and telephone interviews. Data from the Generation R database (prospective cohort study; n = 9667) were used to determine the background risk (controls). Odds ratios and 95% CI were estimated using general estimation equation analysis adjusted for multiple pregnancies per woman, maternal age and parity status.Adjusted odds ratios (AORs) for developing pregnancy complications in relation to corrective status.Pregnancies in women with an unrepaired VSD were associated with a higher risk of pre-eclampsia (AOR 4.59, 95% CI 2.01-10.5, P0.001) compared with controls. No differences were observed when comparing women with repaired VSD and controls. Pregnancies in women with repaired VSD were associated with a higher risk of premature labour (AOR 4.02, 95% CI 1.12-14.4, P = 0.03) and small-for-gestational-age (SGA) births (AOR 4.09, 95% CI 1.27-13.2, P = 0.02) compared with women with unrepaired VSD.Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d644d2c6367037cb34240590c2f424c7 https://pubmed.ncbi.nlm.nih.gov/20156207 Zobrazit plný text záznamu Plný text