| Autor: |
Shixiong, Tian, Chaofeng, Tu, Xiaojin, He, Lanlan, Meng, Jiaxiong, Wang, Shuyan, Tang, Yang, Gao, Chunyu, Liu, Huan, Wu, Yiling, Zhou, Mingrong, Lv, Ge, Lin, Li, Jin, Yunxia, Cao, Dongdong, Tang, Feng, Zhang, Yue-Qiu, Tan |
| Rok vydání: |
2022 |
| Zdroj: |
Journal of medical genetics. |
| ISSN: |
1468-6244 |
| Popis: |
Spermatogenic impairments can lead to male infertility by different pathological conditions, such as multiple morphological abnormalities of the sperm flagella (MMAF) and non-obstructive azoospermia (NOA). Genetic factors are involved in impaired spermatogenesis.Here, we performed genetic analyses through whole-exome sequencing in a cohort of 334 Han Chinese probands with severe MMAF or NOA. Biallelic variants ofOur genetic analyses and experimental observations revealed that biallelic deleterious mutations of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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