[Cytotoxic derivatives of (22R,23R)-22,23-dihydroxystigmastane]

Autor:	F V, Drozdov, A R, Mekhtiev, G E, Morozevich, V P, Timofeev, A Iu, Misharin
Rok vydání:	2007
Předmět:	Sterols Structure-Activity Relationship Cell Survival Cell Line Tumor Humans Antineoplastic Agents Drug Screening Assays Antitumor
Zdroj:	Bioorganicheskaia khimiia. 33(3)
ISSN:	0132-3423
Popis:	(22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23-dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3beta,5alpha,6beta,22,23-pentahydroxystigmastane, (22R,23R)-5alpha,6alpha-oxido-3beta,22,23-trihydroxystigmastane, (22R,23R)-5beta,6beta-oxido-3beta,22,23-trihydroxystigmastane, and (22R,23R)-3beta,6beta,22,23-tetrahydroxystigmast-4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d62f226a00b0a8ec675750caa1941d71 https://pubmed.ncbi.nlm.nih.gov/17682392 Zobrazit plný text záznamu