| Autor: |
V N, Kovalenko, G V, Donchenko, I V, Kuz'menko, N M, Gurina, V P, Makovetskiĭ |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
Voprosy pitaniia. (2) |
| ISSN: |
0042-8833 |
| Popis: |
The efficacy of pharmacopeial alpha-tocopheryl acetate, alpha-tocopheronolactone and the antioxidant diludin was studied as to the possibilities of preventing E-hypovitaminosis muscle dystrophy in rabbits. alpha-Tocopheronolactone action was similar to that of pharmacopeial alpha-tocopheryl acetate as regards E-vitamin activity that was manifested by an increase in the body mass, decrease in the urine creatine index and maintenance of normal ubiquinone content, as well as of succinate-ubiquinone-reductase, NADH-ubiquinone-reductase and NADH-cytochrome c-reductase activity of rabbit skeletal muscle and heart mitochondria. On the contrary , as a result of the antioxidant administration, no direct correlation was found between ubiquinone content and activity of ubiquinone-dependent enzymatic systems of mitochondria. The data obtained attest to high E-vitamin activity of alpha-tocopheronolactone. The action of the latter was disclosed to be different from that produced by the antioxidant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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