HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of

Autor:	Fusanori, Yotsumoto, Satoshi, Fukagawa, Kohei, Miyata, Sung Ouk, Nam, Takahiro, Katsuda, Daisuke, Miyahara, Takashi, Odawara, Sadao, Manabe, Toyokazu, Ishikawa, Shin'ichiro, Yasunaga, Shingo, Miyamoto
Rok vydání:	2017
Předmět:	Mice Inbred BALB C Lung Neoplasms Mice Nude Antineoplastic Agents Apoptosis Gefitinib Tumor Burden ErbB Receptors Bacterial Proteins Cell Line Tumor Mutation Quinazolines Animals Humans Female Molecular Targeted Therapy Protein Kinase Inhibitors Heparin-binding EGF-like Growth Factor
Zdroj:	Anticancer research. 37(7)
ISSN:	1791-7530
Popis:	Advanced lung cancer is one of the most lethal malignancies. Many anticancer agents have been developed for lung cancer with epidermal growth factor receptor (EGFR) mutations, but its prognosis remains extremely poor. The development of molecularly-targeted therapies is required for patients with lung cancer with secondary mutation of the EGFR gene. In this study, in order to assess the validity of heparin-binding EGF-like growth factor (HB-EGF) as a therapeutic target for lung cancer with EGFR mutation, we examined the antitumor effects of a specific inhibitor (cross-reacting material 197; CRM197) on lung cancer cells with EGFR mutation. HB-EGF was the most predominantly expressed EGFR ligand in lung cancer cells with EGFR mutation. CRM197 induced significant cell apoptosis and marked suppression of tumorigenicity in lung cancer cells with single or double mutation of EGFR. These results suggest that HB-EGF is a rational target for the treatment of lung cancer with EGFR mutation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d5ff202e320ef417ed2ebc3b4b9e9d33 https://pubmed.ncbi.nlm.nih.gov/28668882 Zobrazit plný text záznamu