| Autor: |
Jingqiang, Wang, Chunye, Liu, Lingli, He, Zhiyao, Xie, Lanyue, Bai, Wentao, Yu, Zuoyun, Wang, Yi, Lu, Dong, Gao, Junfen, Fu, Lei, Zhang, Yi Arial, Zeng |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
eLife. 11 |
| ISSN: |
2050-084X |
| Popis: |
Ovarian surface epithelium (OSE) undergoes recurring ovulatory rupture and OSE stem cells rapidly generate new cells for the repair. How the stem cell activation is triggered by the rupture and promptly turns on proliferation is unclear. Our previous study has identified that Protein C Receptor (Procr) marks OSE progenitors. In this study, we observed decreased adherent junction and selective activation of YAP signaling in Procr progenitors at OSE rupture site. OSE repair is impeded upon deletion of Yap1 in these progenitors. Interestingly, Procr+ progenitors show lower expression of Vgll4, an antagonist of YAP signaling. Overexpression of Vgll4 in Procr+ cells hampers OSE repair and progenitor proliferation, indicating that selective low Vgll4 expression in Procr+ progenitors is critical for OSE repair. In addition, YAP activation promotes transcription of the OSE stemness gene |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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