BECN1
| Autor: | Salwa, Sebti, Zhongju, Zou, Michael U, Shiloh |
|---|---|
| Rok vydání: | 2022 |
| Zdroj: | Autophagy. |
| ISSN: | 1554-8635 |
| Popis: | Macroautophagy/autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively increases basal autophagy in young mice and reduces cardiac and renal age-related changes in longer lived |
| Databáze: | OpenAIRE |
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