Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T

Autor:	Julian M, Stark, Jielu, Liu, Christopher A, Tibbitt, Murray, Christian, Junjie, Ma, Anna, Wintersand, Josefine, Dunst, Taras, Kreslavsky, Ben, Murrell, Mikael, Adner, Hans, Grönlund, Guro, Gafvelin, Jonathan M, Coquet
Rok vydání:	2022
Předmět:	Disease Models Animal Mice Dogs Th2 Cells Pyroglyphidae Hypersensitivity Respiratory Hypersensitivity Animals Allergens Respiration Disorders Asthma
Zdroj:	Allergy. 77(10)
ISSN:	1398-9995
Popis:	Allergy to dogs affects around 10% of the population in developed countries. Immune therapy of allergic patients with dog allergen extracts has shown limited therapeutic benefit.We established a mouse model of dog allergy by repeatedly administering dog dander and epithelium extracts via the intranasal route. We also assessed the efficacy of a recombinant multimeric protein containing Can f 1, f 2, f 4 and f 6 in preventing inflammatory responses to dog extracts.Repeated inhalation of dog extracts induced infiltration of the airways by TDog allergen extracts induce robust T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d5956541ea9c9370ee048218eb0d35af https://pubmed.ncbi.nlm.nih.gov/35657107 Zobrazit plný text záznamu Plný text