| Autor: |
R M, Shepherd, K E, Cosgrove, R E, O'Brien, P D, Barnes, C, Ammälä, M J, Dunne |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Archives of disease in childhood. Fetal and neonatal edition. 82(2) |
| ISSN: |
1359-2998 |
| Popis: |
Insulin is synthesised, stored, and secreted from pancreatic beta cells. These are located within the islets of Langerhans, which are distributed throughout the pancreas. Less than 2% of the total pancreas is devoted to an endocrine function. When the mechanisms that control insulin release are compromised, potentially lethal diseases such as diabetes and neonatal hypoglycaemia are manifest. This article reviews the physiology of insulin release and illustrates how defects in these processes will result in the pathophysiology of hyperinsulinism of infancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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