| Autor: |
Dorothy, Nakiwala, Pamela D, Noyes, Patrice, Faure, Benoît, Chovelon, Christelle, Corne, Anne Sophie, Gauchez, Dorra, Guergour, Sarah, Lyon-Caen, Amrit K, Sakhi, Azemira, Sabaredzovic, Cathrine, Thomsen, Isabelle, Pin, Rémy, Slama, Claire, Philippat |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Environmental health perspectives. 130(11) |
| ISSN: |
1552-9924 |
| Popis: |
Studies characterizing associations between phenols, phthalates and thyroid hormones during pregnancy produce inconsistent results. This divergence may be partly attributable to false positives due to multiple comparison testing of large numbers of chemicals, and measurement error as studies rely on small numbers of biospecimens despite high intra-individual variability in urinary chemical metabolite concentrations.This study employsA two-tiered approach was implemented:The ToxCast/Tox21 screening reduced the chemical set from 16 to 13 and the associated number of statistical comparisons by 19%. Parabens were negatively associated with free triiodothyronine (T3) and the T3/T4 (total thyroxine) ratio. Monobenzyl phthalate was positively associated with total T4 and negatively with the T3/T4 ratio. Effect modification by iodine status was detected for several compounds (among themFor these chemicals, screening for compounds with an increased likelihood for thyroid-related effects and relying on repeated urine samples to assess exposures improved the overall performance of multichemical analyses of thyroid disruption. This approach may improve future evaluations of human data for the thyroid pathway with implication for fetal health and may serve as a model for evaluating other toxicity outcomes. https://doi.org/10.1289/EHP10239. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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