Antimicrobial efficacy of triple antibiotic-loaded chitosan nanoparticles activated with photochemical disinfection: A microbiological and confocal microscopic analysis

Autor: Vivek, Hegde, S, Srilatha, Amulya, Vangala, Naqiyaa, Khandwawalla, Asiya, Mujawar
Rok vydání: 2021
Zdroj: Journal of conservative dentistry : JCD. 25(3)
ISSN: 0972-0707
Popis: This105 single-rooted extracted teeth were decoronated, cleaned and shaped, and incubated with Ef. The roots were randomly divided into three groups: Group I-Control, Group II-Triple Antibiotic Paste (TAP), Group III: Triple antibiotic-loaded chitosan nanoparticles (tachnp), and Group IV: Tachnp and TBO loaded chnp activated with PDT. Ten specimens from all the groups were subjected to antimicrobial analysis and five specimens were observed under the confocal microscope after 24 h and 7 days. Group IV was additionally analyzed after 24 h and 7 days of laser activation.Group IV C showed the least colony-forming units followed by Group IVB, Group IIIB, Group IVA, and Group IIIA. Group II showed more colony-forming units. On intergroup comparison of mean colony count in control and experimental groups at 24 h and 7 days using one-way ANOVA F test was highly significantWithin the limitations of this study, TAP loaded chitosan nanoparticles activated with PDT showed a significant reduction in colony count.
Databáze: OpenAIRE