[Diethylnicotinamid (cordiamine) stabilization of the liver hydroxylating function in rabbits with CCl4 poisoning]

Autor:	L B, Zavodnik, M I, Bushma, P I, Lukienko, G Z, Abakumov, I V, Zverinskiĭ, V M, Tsyrkunov
Rok vydání:	1991
Předmět:	Male Time Factors Liver Carbon Tetrachloride Poisoning Nikethamide Drug Evaluation Preclinical Animals Alanine Transaminase Bilirubin Rabbits Hydroxylation Antipyrine
Zdroj:	Farmakologiia i toksikologiia. 54(4)
ISSN:	0014-8318
Popis:	Three and ten days after the administration of CCl4 (subcutaneously, once, 4 ml/kg of 50% oil solution) there were found a decrease of the rate of antipyrine elimination (intravenously, 50 mg/kg) from the blood plasma, an increase of the total bilirubin content, ALT activity and stimulation of lipid peroxidation processes. Cordiamine administration (subcutaneously, twice a day, 3 and 10 days) exerts the normalizing effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d52ae1d972c255982672782176000588 https://pubmed.ncbi.nlm.nih.gov/1786835 Zobrazit plný text záznamu