| Autor: |
D A, Lewis, D, Ganderton, B J, Meakin, G, Brambilla |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Respiration; international review of thoracic diseases. 72 |
| ISSN: |
0025-7931 |
| Popis: |
The development of HFA-based pMDIs has proved difficult due to differences in the physico-chemical properties of CFC and HFA propellants. However, the development of solution formulations instead of suspensions has provided a way to formulate products whose cloud characteristics can be modulated in a controlled manner by permitting different formulation and device hardware variables. The new approach has proved successful in formulating several different drugs including steroids and has now been applied to developing a formoterol Modulite solution formulation characterized by good chemical stability, delivery performance, and clinical results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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