| Autor: |
Seikou, Nakamura, Jiang, Liu, Souichi, Nakashima, Keiko, Ogawa, Takashi, Ueda, Eri, Onishi, Kiwako, Kurooka, Yuko, Moriwaki, Kaori, Ryu, Bin, Xu, Takahiro, Matsumoto, Tomoe, Ohta, Masashi, Fukaya, Masayuki, Yoshikawa, Hisashi, Matsuda |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Natural product communications. 11(8) |
| ISSN: |
1934-578X |
| Popis: |
A coumaric acid analogue with a monoterpene moiety named floraosmanol A (1) was isolated from the flowers of Osmanthisfragrans var. aurantiacus. The chemical structure was elucidated on the basis of chemical and physicochemical evidence. Floraosmanol A (1) significantly inhibited nitric oxide .(NO) production in lipopolysaccharide- (LPS) activated RAW264.7 macrophages and the release of P-hexosaminidase as a marker of degranulation from rat basophile leukemia (RBL-2H3) cells. In addition, several cinnamic acid analogues were conjugated with geraniol and 3-methyl-2-buten-1-ol through an ester linkage. The inhibitory effects on NO production and the release of P-hexosaminidase of the synthesized compounds were examined for structure-activity relationships. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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