Decreased expression of liver-type fatty acid-binding protein is associated with poor prognosis in hepatocellular carcinoma
| Autor: | Bin, Wang, Xuan, Tao, Chuan-Zhong, Huang, Jing-Feng, Liu, Yun-Bin, Ye, Ai-Min, Huang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Aged 80 and over Male Carcinoma Hepatocellular Time Factors Reverse Transcriptase Polymerase Chain Reaction Liver Neoplasms Down-Regulation Kaplan-Meier Estimate Middle Aged Fatty Acid-Binding Proteins Prognosis Real-Time Polymerase Chain Reaction Immunohistochemistry Predictive Value of Tests Risk Factors Tissue Array Analysis Case-Control Studies Biomarkers Tumor Humans Female RNA Messenger Aged |
| Zdroj: | Hepato-gastroenterology. 61(133) |
| ISSN: | 0172-6390 |
| Popis: | The purpose of this study was to assess liver-type fatty acid-binding protein (L-FABP) expression and its association with clinicopathological features in hepatocellular carcinoma (HCC).L-FABP mRNA expression in 57 samples of HCC and corresponding adjacent liver tissue and 8 normal liver tissue samples were examined by real-time reverse transcriptase (RT)–PCR analyses. Tissue microarray technique and immunohistochemistry (IHC) were used to detect the expression of L-FABP in 163 HCCs. The association between L-FABP expression and the clinicopathological factors and prognosis was analyzed.The average expression of L-FABP mRNA was 0.233 in the HCC tissues, 1.407 in the peri-carcinoma tissues, and 1.0 in the normal liver tissues. IHC analysis showed that there were 47% (76/163) HCCs exhibited weak or even no immunoreactivity of L-FABP. The L-FABP expression in HCC showed significant associations with preoperative levels of AFP (p=0.039), tumor size (p=0.026), histological grade (p=0.000), differential degree (p=0.000), vascular invasion (p=0.016), capsular invasion (p=0.029) and recurrence (p=0.004). Patients with L-FABP high-expression showed better prognosis than patients with L-FABP low-expression (p=0.008).L-FABP was downregulated in HCC and could be served as a promising prognostic marker for HCC patients. |
| Databáze: | OpenAIRE |
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