| Autor: |
Raúl R, Rodrigues-Diez, Antonio, Tejera-Muñoz, Macarena, Orejudo, Laura, Marquez-Exposito, Laura, Santos, Sandra, Rayego-Mateos, Elena, Cantero-Navarro, Lucia, Tejedor-Santamaria, Vanessa, Marchant, Alberto, Ortiz, Jesús, Egido, Sergio, Mezzano, Rafael, Selgas, Juan F, Navarro-González, Jose M, Valdivielso, Carolina, Lavoz, Marta, Ruiz-Ortega |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Nefrologia. 41(3) |
| ISSN: |
2013-2514 |
| Popis: |
Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immune system, predominantly Th17 lymphocytes and γδ lymphocytes. In this paper, we review the role of IL-17A in the pathogenesis of hypertension and target organ damage. Studies in mice have shown that IL-17A increases blood pressure, probably by acting on multiple levels. Furthermore, IL-17A plasma concentrations are already elevated in patients with mild or moderate hypertension. Preclinical studies on arterial hypertension have detected IL-17A-producing cells in target organs such as the heart, vessels and kidneys. Patients with hypertensive nephrosclerosis show kidney infiltration by Th17 lymphocytes and γδ lymphocytes that express IL-17A. In addition, in experimental models of hypertension, blocking IL-17A by genetic strategies, or using neutralising antibodies, lowers blood pressure by acting on the vascular wall and tubule sodium transport and reduces damage to target organs. As a whole, the data presented in this review suggest that IL-17A participates in the regulation of blood pressure and in the genesis and maintenance of arterial hypertension, and may constitute a therapeutic target in the future. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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