Impacts of Yangxin decoction on the expressions of MMP-9, CaN, NFAT3 and GATA4 in myocardial tissue of rats with chronic heart failure
| Autor: | Qing, Yang, Zhongyi, Qian |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Heart Failure
Male NFATC Transcription Factors Ventricular Remodeling Calcineurin Myocardium Nerve Tissue Proteins Stroke Volume Recovery of Function Ventricular Function Left GATA4 Transcription Factor Rats Sprague-Dawley Disease Models Animal Matrix Metalloproteinase 9 Chronic Disease Ventricular Pressure Animals Female Drugs Chinese Herbal |
| Zdroj: | Pakistan journal of pharmaceutical sciences. 34(5(Special)) |
| ISSN: | 1011-601X |
| Popis: | To investigate the impacts of Yangxin decoction on the expressions of matrix metalloproteinase 9 (MMP-9), calcineurin (CaN), T cell activated nuclear factor 3 (NFAT3) and zinc finger transcription factor 4 (GATA4) in myocardial tissue of rats with chronic heart failure (CHF). 50 healthy SD rats were randomly divided into the normal control group (n = 10) and the operation group (n = 40). After successful modeling, the rats were randomly divided into 4 groups. And they were treated with Yangxin decoctions of low concentration (1.5 g/kg), medium concentration (2.5 g/kg), high concentration (3.5 g/kg) and distilled water (for 4 weeks). The LVSP, SAP, DAP and LVEDP in Yangxin decoction treatment groups were significantly superior to the model group. The LVEF, LVIDd and LVIDs in Yangxin decoction treatment groups were significantly superior to the model group. The activity of CaN in each group treated with Yangxin decoction was significantly lower than that in the model group. The expression levels of MMP-9, NFAT3, GATA4 protein in each group treated with Yangxin decoction were significantly lower than that in the model group.. Yangxin decoction can significantly improve the cardiac function, reduce CaN activity, decrease the expression levels of MMP-9, NFAT3 and GATA4, inhibit CaN/NFAT3 signaling pathway, increase myocardial remodeling and protect myocardial tissue in rats with CHF. |
| Databáze: | OpenAIRE |
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