| Autor: |
Seong Jeong, Park, Ji-Hae, Kim, Mi-Young, Song, Young Chul, Sung, Seung-Woo, Lee, Yunji, Park |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
BMB Reports |
| ISSN: |
1976-670X |
| Popis: |
Programmed cell death-1 (PD-1) is a coinhibitory molecule and plays a pivotal role in immune regulation. Here, we demonstrate a role for PD-1 in pathogenesis of inflammatory bowel disease (IBD). Wild-type (WT) mice had severe wasting disease during experimentally induced colitis, while mice deficient for PD-1 (PD-1−/−) did not develop colon inflammation. Interestingly, PD-1−/− mice cohoused with WT mice became susceptible to colitis, suggesting that resistance of PD-1−/− mice to colitis is dependent on their gut microbiota. 16S rRNA gene-pyrosequencing analysis showed that PD-1−/− mice had altered composition of gut microbiota with significant reduction in Rikenellaceae family. These altered colon bacteria of PD-1−/− mice induced less amount of inflammatory mediators from colon epithelial cells, including interleukin (IL)-6, and inflammatory chemokines. Taken together, our study indicates that PD-1 expression is involved in the resistance to experimental colitis through altered bacterial communities of colon. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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