| Autor: |
Meng-Jia, Wu, Cheng-Lin, Tang, Si-Qin, Huang, Dan-Dan, Zhao, Ao, Luo, An-Ning, Zhang, Hui-Yu, An, Cheng-Fang, Tan, Li, Qiu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Zhen ci yan jiu = Acupuncture research. 44(4) |
| ISSN: |
1000-0607 |
| Popis: |
To observe the effect of electroacupuncture (EA) on morphological changes of denervated gastrocnemius(GS) and the expression of fork-head protein(FOXO3A), muscle atrophy F-box(MAFbx)and myogenic differentiation antigen (Myod1) in sciatic nerve injury rats, so as to reveal its mechanism underlying improvement of myoatrophy.Eighteen male Sprague-Dawley rats were randomly divided into sham operation, model and EA groups (Following modeling, the GS wet weight ratio, CSA and fiber diameter were smaller in the model group than those in the sham group (EA of ST36 and GB30 can suppress the up-regulated expression of FOXO3A and MAFbx mRNA and protein and further promote the expression of Myod1 mRNA and protein in the GS tissue in rats with denervated GS atrophy, which may contribute to its function in relieving the myoatrophy, promoting the skeletal muscle protein hydrolysis and differentiation of satellite cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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