| Autor: |
A A, Litvin, G B, Kolyvanov, P O, Bochkov, R V, Shevchenko, A L, Podol'ko, K N, Kolyasnikova, V P, Zherdev |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Bulletin of experimental biology and medicine. 172(3) |
| ISSN: |
1573-8221 |
| Popis: |
We studied the pharmacokinetics of GZK-111 (N-phenylacetyl-glycyl-L-proline ethyl ether), a compound with neuroprotective activity, and its metabolite CPG (cyclo-L-prolylglycine) in rat blood plasma after single intravenous and intragastric administration in a dose of 20 mg/kg. It was found that the parent drug undergoes intensive biotransformation; its metabolite CPG persists in the circulation more than twice as long as GZK-111 and its plasma concentrations were higher by 50-70 times than the concentrations of the parent compound. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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