| Popis: |
Body mass index (BMI) overweight/obesity thresholds in South Asian (SA) adults, at equivalent type 2 diabetes risk are lower than for white Europeans (WE). We aimed to define adjusted overweight/obesity thresholds for UK SA children based on equivalent insulin resistance (HOMA-IR) to WE children. In 1138 WE and 1292 SA children 9.0-10.9y, multi-level regression models quantified associations between BMI and HOMA-IR, by ethnic group. HOMA-IR levels for WE children were calculated at established overweight/obesity thresholds (9.5y,10.5y), based on UK90 BMI cut-offs. Quantified associations in SA children were then used to estimate adjusted SA weight status thresholds at the calculated HOMA-IR levels. At 9.5y, current WE BMI overweight and obesity thresholds were 19.2kg/m2, 21.3kg/m2 (boys) and 20.0kg/m2, 22.5kg/m2 (girls). At equivalent HOMA-IR, SA overweight and obesity thresholds were lower by 2.9kg/m2 (95%CI: 2.5–3.3kg/m2) and 3.2kg/m2 (95%CI: 2.7–3.6kg/m2) in boys and 3.0kg/m2 (95%CI: 2.6–3.4kg/m2) and 3.3kg/m2 (95%CI: 2.8–3.8kg/m2) in girls respectively. At these lower thresholds, overweight/obesity prevalences in SA children were approximately doubled (boys:61%,girls:56%). Patterns at 10.5y were similar. In conclusion, SA adjusted overweight/obesity thresholds based on equivalent IR, were markedly lower than BMI thresholds for WE children and defined more than half of SA children as overweight/obese. |
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