The angiogenic growth factors HGF and VEGF in serum and plasma from neuroblastoma patients
| Autor: | Erik G, Sköldenberg, Anders, Larsson, Ake, Jakobson, Fredrik, Hedborg, Per, Kogner, Rolf H, Christofferson, Faranak, Azarbayjani |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Oncogene Proteins Vascular Endothelial Growth Factor A N-Myc Proto-Oncogene Protein Ploidies Hepatocyte Growth Factor Infant Newborn Infant Loss of Heterozygosity Nuclear Proteins Enzyme-Linked Immunosorbent Assay Prognosis Neuroblastoma Case-Control Studies Child Preschool Humans Multicenter Studies as Topic Female Child |
| Zdroj: | Anticancer research. 29(8) |
| ISSN: | 1791-7530 |
| Popis: | To determine whether concentrations of the angiogenic growth factors hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGF-A) correlate with clinical and genetic markers in samples taken at diagnosis in children with neuroblastoma (NB).Heparin plasma (P-) and serum (S-) samples of healthy controls (n=73, mean age +/- SD 3.5+/-2.1; females/males: 23/50) and patients with NB (n=62; 2.2+/-1.8; 26/36) were collected between 1988 and 1999. Clinical data included age at diagnosis, gender, stage, outcome, amplification of the oncogene MYCN, loss of heterozygosity at the short arm of chromosome 1 (1p LOH) and ploidy.HGF and S-VEGF-A were elevated in NB as compared to controls (38/62 patients, p0.0001 and p0.05, Mann-Whitney U test). HGF concentrations were higher in high-stage (stage 3-4) as compared to low-stage (stage 1-2) disease (p0.01). P-HGF was elevated in patients with 1p LOH (p0.01), MYCN amplification (p0.001) and di- or tetraploidy (p0.001). S-HGF concentration was elevated in patients MYCN-amplified tumors only. Plasma and S-HGF concentrations were higher in the deceased group (p0.05), but not P or S-VEGF-A.This study showed that concentrations of HGF and S-VEGF-A are elevated in patients with NB. Furthermore, HGF and S-VEGF-A concentrations correlate to higher stage disease and HGF correlates to genetic markers known to indicate a poor outcome. These observations imply that HGF and VEGF-A have biological roles in NB and suggest the possibility of interference with HGF or VEGF-A signaling as a therapeutic strategy. |
| Databáze: | OpenAIRE |
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