Evaluating the hepatoprotective, ameliorative and antioxidant potentials of the crude aqueous leafy extracts of
| Autor: | Fidelis Azagbor, Ilukho, Olumuyiwa John, Fasipe, Flora Ruth, Aigbe |
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| Rok vydání: | 2021 |
| Zdroj: | Future science OA. 8(6) |
| ISSN: | 2056-5623 |
| Popis: | Drug-induced hepatotoxicity is a major public health issue of concern. It significantly affects the development of new pharmaceutical drugs and has led to the withdrawal of many promising pharmaceutical drugs from the pharmaceutical market.The aim of this study was to evaluate the hepatoprotective, ameliorative and antioxidant effects of the crude aqueous leafy extract ofTwelve different groups of six mice (three males and three females) were used for this study. Acetaminophen at a single lethal hepatotoxic dose of 3 g/kg was orally administered on the seventh day to the mice in groups 2 to 12 after their 6-day pretreatment duration for the induction of hepatotoxicity; and were then left for 24 hours before the collection of specimen samples were completed, while group 1 served as control.The crude aqueous leafy extract ofThe findings from this study demonstrated that the crude aqueous leafy extract of |
| Databáze: | OpenAIRE |
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