| Autor: |
Nicholas E, Houstis, Aaron S, Eisman, Paul P, Pappagianopoulos, Luke, Wooster, Cole S, Bailey, Peter D, Wagner, Gregory D, Lewis |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Circulation. 137(2) |
| ISSN: |
1524-4539 |
| Popis: |
Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with a pressing shortage of therapies. Exercise intolerance is a cardinal symptom of HFpEF, yet its pathophysiology remains uncertain.We investigated the mechanism of exercise intolerance in 134 patients referred for cardiopulmonary exercise testing: 79 with HFpEF and 55 controls. We performed cardiopulmonary exercise testing with invasive monitoring to measure hemodynamics, blood gases, and gas exchange during exercise. We used these measurements to quantify 6 steps of oxygen transport and utilization (the OPeak VoSystematic analysis of the O |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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