Arterial blood gases, pulmonary function and pathology in rats exposed to 0.75 or 1.0 ppm ozone

Autor:	W E, Pepelko, J K, Mattox, Y Y, Yang
Rok vydání:	1980
Předmět:	Male Oxygen Ozone Body Weight Animals Blood Gas Analysis Carbon Dioxide Hydrogen-Ion Concentration Lung Volume Measurements Lung Lung Compliance Rats Respiratory Function Tests
Zdroj:	Journal of environmental pathology and toxicology. 3(5-6)
ISSN:	0146-4779
Popis:	Arterial blood gases, residual lung volume (RV), deflation pressure volume (PV) curves, pulmonary pathology and body weight changes were studied in rats exposed up to 14 days to either 0.75 or 1.0 ppm ozone. Arterial PO2 and body weights decreased progressively with length of exposure while PaCO2 and RV increased. The slope of the PV curve decreased in all groups exposed to ozone. Pathological changes in the lung increased in severity with concentration and length of exposure. The present findings have shown that arterial blood gas measurements represent a sensitive index of altered lung function in rats, a species very sensitive to ozone exposure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d413d074d1a352746cdb10783bdbac23 https://pubmed.ncbi.nlm.nih.gov/6777444 Zobrazit plný text záznamu