Pattern recognition receptor-mediated cytokine response in infants across 4 continents
| Autor: | Kinga K, Smolen, Candice E, Ruck, Edgardo S, Fortuno, Kevin, Ho, Pedro, Dimitriu, William W, Mohn, David P, Speert, Philip J, Cooper, Monika, Esser, Tessa, Goetghebuer, Arnaud, Marchant, Tobias R, Kollmann |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Innate immunity
PGN Peptidoglycan infectious disease Toll-Like Receptors PCA Principal-component analysis Infant PRR Pattern-recognition receptor Infections global Immunity Innate MDP Muramyl dipeptide Immune Deficiencies Infection and Systemic Immune Disorders immune development Child Preschool Receptors Pattern Recognition Infant Mortality NOD Nucleotide-binding oligomerization domain-containing protein Cytokines Humans R848 Resiquimod Disease Susceptibility Poly I:C Polyinosinic-polycytidylic acid LPS Lipopolysaccharide TLR Toll-like receptor |
| Zdroj: | The Journal of Allergy and Clinical Immunology |
| ISSN: | 1097-6825 |
| Popis: | Background Susceptibility to infection as well as response to vaccination varies among populations. To date, the underlying mechanisms responsible for these clinical observations have not been fully delineated. Because innate immunity instructs adaptive immunity, we hypothesized that differences between populations in innate immune responses may represent a mechanistic link to variation in susceptibility to infection or response to vaccination. Objective Determine whether differences in innate immune responses exist among infants from different continents of the world. Methods We determined the innate cytokine response following pattern recognition receptor (PRR) stimulation of whole blood from 2-year-old infants across 4 continents (Africa, North America, South America, and Europe). Results We found that despite the many possible genetic and environmental exposure differences in infants across 4 continents, innate cytokine responses were similar for infants from North America, South America, and Europe. However, cells from South African infants secreted significantly lower levels of cytokines than did cells from infants from the 3 other sites, and did so following stimulation of extracellular and endosomal but not cytosolic PRRs. Conclusions Substantial differences in innate cytokine responses to PRR stimulation exist among different populations of infants that could not have been predicted. Delineating the underlying mechanism(s) for these differences will not only aid in improving vaccine-mediated protection but possibly also provide clues for the susceptibility to infection in different regions of the world. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect