| Popis: |
Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis. |
