| Autor: |
L I, Ershova, Z M, Likhovetskaia, G N, Kurbanova, S P, Shcherbinina, N A, Gorbunova |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Terapevticheskii arkhiv. 70(11) |
| ISSN: |
0040-3660 |
| Popis: |
To establish changes of and correlations between erythrodieresis and blood rheology in hereditary hemochromatosis (HHC).Hemorheologic indices (asymptomatic blood and plasma viscosity, that of blood at low shift speed, red cell deformity and aggregation) were studied in 42 HHC patients and 23 healthy donors. The patients were divided into groups by homozygous (groups 1 and 2) or heterozygous (groups 3 and 4) allel genes and sex (females-groups 2 and 4, males-groups 1 and 3).All the patients had increased resistance of red cells in high percentage of their high-resistance populations (correlation index 0.8-0.9) due to destruction and elimination from the circulation. These changes were more pronounced in males, similar in homo- and heterozygotes. The presence in the peripheral blood of red cells with high resistance is associated with a 25-30% decrease in the red cell rigidity, in groups 1 and 3 this decrease reached 30-40%. To a certain degree high deformity and aggregation of red cells is explained by high plasma viscosity (correlation index 0.4). Plasma viscosity was high in all the patients of all groups.HHC runs with rejuvenascence of erythroid cells. Changed activity of erythrodieresis and damage to red cells at the level of microcirculation may be involved in iron metabolism disturbance and development of tissue hemosiderosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
