Effect of Mild Traumatic Brain Injury on Behavioral Reactions and Neocortical Morphology in Rats

Autor:	N G, Plekhova, I V, Radkov, S V, Zinoviev, I V, Dyuizen, A N, Baryshev, V B, Shumatov
Rok vydání:	2020
Předmět:	Male Neurons Disease Models Animal Brain Injuries Brain Injuries Traumatic Animals Brain Neocortex Rats Wistar Brain Concussion Rats
Zdroj:	Bulletin of experimental biology and medicine. 170(5)
ISSN:	1573-8221
Popis:	The original weight-drop model was employed to examine the effect of mild traumatic brain injury (TBI) on behavioral phenotype and neocortical morphology in rats. The neurological examination of rats with moderate TBI revealed the focal symptoms corresponding to pronounced neurological disorders, whereas in rats after mild TBI, there were only minor coordination disorders. On day 7 after injury, the rats with mild TBI demonstrated enhanced anxiety assessed by conditioned passive avoidance response. The morphometric analysis of the brain tissues revealed narrowing of the capillaries and increased score of hyperchromic neocortical neurons, which attested to cerebral hypoxia. The manifestations of mild TBI in original rat model demonstrated a close similarity to the symptoms of TBI in humans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d3b052ab708645206df4174a88b1cec7 https://pubmed.ncbi.nlm.nih.gov/33788107 Zobrazit plný text záznamu Full text from SpringerLink