[A case of recurrent breast cancer with extensive liver metastasis successfully treated with endocrine therapy]
| Autor: | Sachiko, Kiyoto, Fumikata, Hara, Shozo, Osumi, Daisuke, Takabatake, Seiki, Takashima, Kenjiro, Aogi, Shigemitsu, Takashima |
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| Rok vydání: | 2009 |
| Předmět: |
Medroxyprogesterone
Antibiotics Antineoplastic Antineoplastic Agents Hormonal Liver Neoplasms Antineoplastic Agents Breast Neoplasms Middle Aged Triazoles Androstadienes Tamoxifen Doxorubicin Antineoplastic Combined Chemotherapy Protocols Letrozole Nitriles Humans Female Toremifene Neoplasm Recurrence Local Antineoplastic Agents Alkylating Cyclophosphamide |
| Zdroj: | Gan to kagaku ryoho. Cancerchemotherapy. 36(13) |
| ISSN: | 0385-0684 |
| Popis: | A 5 6-year-old woman, who underwent breast-conserving surgery and radiation (60 Gy) therapy in July, 1992, at the age of 40, was diagnosed with pT1aN0M0, pStage I. She was administered tamoxifen (TAM) as adjuvant therapy. However, she underwent microdochectomy for DCIS in her contralateral breast in June, 1998. TAM was given till August, 1999. In June, 2006, at the age of 54, 14 years after initial surgery, CT revealed extensive liver masses which were diagnosed as liver metastasis by liver biopsy. Receptor status was positive for ER and PgR, and negative for HER2. AC was started as a first-line chemotherapy ( 4 courses), but did not prove effective. She refused second-line chemotherapy, so letrozole was selected, and subsequently resulted in PR of the liver metastasis. However, 8 months later, with a liver metastasis relapse, exemestane followed by tamoxifen, medroxyprogesterone acetate, and high-dose toremifene were administered sequentially, resulting in long-time disease control. In conclusion, endocrine therapy might be an effective option even in a visceral crisis, if metastatic tumors have showed slow growth and there is positive hormone receptor status. |
| Databáze: | OpenAIRE |
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