| Autor: |
Kiara, Bruggeman, Meng, Zhang, Nicolo, Malagutti, Shiva, Soltani Dehnavi, Richard, Williams, Antonio, Tricoli, David, Nisbet |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS applied materialsinterfaces. 14(10) |
| ISSN: |
1944-8252 |
| Popis: |
Nanoparticles are popular delivery vehicles, but their diffusional release results in inconstant drug delivery. Here, we flatten the delivery profile into a more constant, zero-order profile. Brain-derived neurotrophic factor (BDNF) is attached to photoactive titanium dioxide nanoparticles and loaded into a nanofibrous self-assembling peptide (SAP) hydrogel. Different UV exposure conditions show three distinct profiles, including a counterintuitive decrease in release after UV exposure. We propose that the adsorption of the freed growth factor onto the hydrogel nanofibers affects release. Nanoparticles diffuse from the hydrogel readily, carrying the bound growth factor, but the freed growth factor (released from the nanoparticles by UV) instead interacts with─and is released less readily from─the hydrogel. UV shifts growth factor from nanoparticles to the hydrogel, therefore changing the diffusional release. Through midpoint UV exposure, we achieve a flattened delivery profile─unusual for diffusion─by changing |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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