| Autor: |
Bruce D, Cheson, Nancy L, Bartlett, Julie M, Vose, Andres, Lopez-Hernandez, Amanda L, Seiz, Anne T, Keating, Setareh, Shamsili, Kyriakos P, Papadopoulos |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Cancer. 118(12) |
| ISSN: |
1097-0142 |
| Popis: |
Few effective therapeutic options exist for patients with refractory diffuse large B-cell lymphoma (DLBCL). YM155 is a survivin suppressant with activity against DLBCL in a phase I trial. This phase II study was conducted to better characterize the toxicity and efficacy of this small molecule in patients with refractory DLBCL.Forty-one patients with a median age of 66 years and 3 prior regimens were enrolled and treated with a YM155 dose of 5 mg/m(2)/d by continuous infusion for 168 hours every 21 days for up to 15 cycles of treatment. The median number of completed cycles was 3.One patient had a complete remission (CR) (2.4%) with an additional 2 patients (5.9%) responding, with a median progression-free survival of 58 days.YM155 was well tolerated with major toxicities including anemia and fatigue. Whereas YM155 had limited single-agent activity, preclinical data suggest its role in combination with other agents, including rituximab, and a study of that combination in ongoing. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text