| Autor: |
T, Fedchenko, O, Izmailova, V, Shynkevych, O, Shlykova, I, Kaidashev |
| Rok vydání: |
2022 |
| Zdroj: |
PPAR research. 2022 |
| ISSN: |
1687-4757 |
| Popis: |
The master clock, which is located in the suprachiasmatic nucleus (SCN), harmonizes clock genes present in the liver to synchronize life rhythms and bioactivity with the surrounding environment. The reversed feeding disrupts the expression of clock genes in the liver. Recently, a novel role of PPAR-Mice were randomly assigned to daytime-feeding and nighttime-feeding groups. Mice in daytime-feeding groups received food from 7 AM to 7 PM, and mice in nighttime-feeding groups received food from 7 PM to 7 AM. PG was administered in the dose of 20 mg/kg per os as aqueous suspension 40 Administration of PG at 7 AM to nighttime-feeding mice did not reveal any influence on the expression of the clock or inflammation-related genes either at midnight or at noon. In the daytime-feeding group, PG intake at 7 PM led to an increase inOur study indicates that reversed feeding induced the disruption of mouse liver circadian expression pattern of clock genes accompanied by increasing |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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